ATS 2026: PABPC4 gene identified as a key driver of emphysema in COPD - Pharmaceutical Technology

PABPC4 genetic variants found to be associated with mitochondrial dysfunction driving emphysema in COPD. PABPC4 genetic variants found to be associated with mitochondrial dysfunction driving emphysema in COPD. Genetic knockout of PABPC4 led to emphysema in mice. Photo by pocketlight//E+ via Getty Images. At the American Thoracic Society (ATS) 2026 annual meeting on 18 May, during the B109 cellular, genetics, and developmental drivers of COPD, emphysema and sarcopenia session, investigators from Vanderbilt University and the Universities of Pittsburgh and North Carolina as well as Tgen presented compelling data identifying PABPC4 (polyadenylate-binding protein cytoplasmic-4) as a novel genetic driver of chronic…

Source: Pharmaceutical Technology