Can smarter technology selection help de-risk small-molecule development? - Pharmaceutical Technology

Predictive modelling for drug formulation helps developers select promising approaches and identify manufacturing challenges earlier. How early identification of solubility, permeability and solid-state risks can prevent costly reformulation and manufacturing problems. Predictive modelling can help drug developers focus laboratory testing on promising formulations and identify manufacturing challenges earlier. Credit: Shutterstock For a small-molecule drug candidate, a compound must dissolve, reach the required exposure, remain stable and be manufactured consistently at progressively larger scales, but these requirements are becoming harder to reconcile as development pipelines include increasingly complex molecules. Adding to the challenge, the consequences often emerge only after formulation work…

Source: Pharmaceutical Technology